Hybrid operations, by definition, utilize multiple different processes; in most cases, 3D printing and CNC milling. Toolpaths for each process will be generated by separate pieces of software. The general flow is as follows:

From the CAD modelling software (such as Fusion360 or Solidworks), the model file of the printed portion is exported to Simplify3D, then printed on the H-Series machine. Back in the CAD (/CAM) software, the toolpaths can be generated to perform subtractive operations on the previously printed part.